Review
Innate immune modulation in EBV infection
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Correspondence: Shunbin Ning sning@med.miami.edu
Viral Oncology Program, Sylvester Comprehensive Cancer Center; Division of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Herpesviridae 2011, 2:1 doi:10.1186/2042-4280-2-1
Published: 5 January 2011Abstract
Epstein-Barr Virus (EBV) belongs to the gammaherpesvirus family, members of which are oncogenic. Compared with other closely related herpesviruses, EBV has developed much more elaborate and sophisticated strategies for subverting host immune system, which may account for its high prevalence in immune competent hosts. Thus, study of EBV-specific immune dysregulation is important for understanding EBV latency and oncogenesis, and will identify potential molecular targets for immunotherapeutic interventions. Here I summarize the recent findings of individual EBV products in regulating host immune responses, with emphasis on the innate immune modulation.